Rotary movement of DNA rotors on nanopores. Prime row: raw online video in the Cy5 channel of each rotor. Center row: corresponding solitary-particle localization results of both equally ends of your DNA rotors. The placement of the current frame is marked as orange and blue dots, and the trajectory of the 10 frames before The present body is demonstrated as solid strains.
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‘It absolutely was merely a make any difference of selecting up a reserve on cell biology and starting to browse. I had come from a earth of ultra-large vacuums, cryostats and quantum phenomena, and now I had been Doing the job at space temperature with molecular biology kits.
Since 2000, Dekker has shifted the main focus of his work towards biophysics where he studies the properties of one biomolecules and cells utilizing the instruments of nanotechnology. This variation of discipline was driven by his fascination for the remarkable performing of Organic molecular constructions, and also through the extended-term standpoint that numerous appealing discoveries might be anticipated in this industry.[five] Existing lines of investigate in his biophysics team are inside the parts of:[six]
2012, discovery that nucleoid occlusion underlies the accuracy of bacterial mobile division; and 1st ever review from the dynamics DNA supercoils and the invention of supercoil hopping
The coiled-coil from the human Rad50 DNA maintenance protein has distinct segments of elevated adaptability
Duration Charge of specific carbon nanotubes by nanostructuring Together with the scanning tunneling microscope
Example (one) of bending configurations in 3D simulations of DNA rods on nanopores. A portion of the membrane is demonstrated in gray, the rim on the pore is highlighted in red, plus a 3D rendering of the movement of the DNA rod is shown.
2003, demonstrated the very first biosensors produced out of a carbon nanotube; fixed the composition and system of DNA fix proteins; and discovery of a fresh method for fabricating solid-point out nanopores for DNA translocation
Dekker began his exploration on single carbon nanotubes in 1993 when he build a brand new line of exploration to study electrical transport by single organic and natural molecules between nanoelectrodes. In 1996 a breakthrough was recognized with carbon nanotubes. This was realized inside a collaboration Together with the team of Nobel laureate Richard Smalley. STM and nanolithography strategies had been used to display that these nanotubes are quantum wires at The only-molecule amount, with outstanding Bodily Houses.
Given that 2000 he moved to single-molecule biophysics and nanobiology, with exploration from scientific studies of DNA loop extrusion and supercoiling to DNA translocation through nanopores. Additional not too long ago his research has centered on researching chromatin construction and mobile division with microorganisms on chip, while he is likewise aiming to in the end Create synthetic cells from the bottom up.
1999, initially measurement of the wavefunction of solitary molecular orbitals of ceesdekker.net carbon nanotubes; and discovery of kink heterojunctions of carbon nanotubes which gave decisive proof for just a new Luttinger description of interacting electrons in nanotubes
2005, discovery of the mechanism of DNA uncoiling by topoisomerase enzymes; discovery of extensive-array conformational changes in Mre11/DNA repair service complexes; and 1st pressure measurements with a DNA molecule inside a nanopore
Supercoiling-dependent DNA binding: quantitative modeling and applications to bulk and one-molecule experiments